ABSTRACT BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple joints. It is associated with psoriasis and treated with synthetic and biologic drugs. OBJECTIVE: The objective of this study was to assess the outcomes of patients who received biologic therapy with tumor necrosis factor (TNF) inhibitors in terms of effectiveness, safety, functionality, and quality of life. DESIGN AND SETTING: A prospective observational study was performed at a single center in Belo Horizonte, Brazil. METHODS: Patients with PsA who received their first TNF inhibitor treatment were followed up for 12 months. Disease activity was measured using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Clinical Disease Activity Index (CDAI). Functionality was measured using the Health Questionnaire Assessment (HAQ), and quality of life was evaluated using the European Quality of Life Five Dimensions (EQ-5D). Multiple linear regression was used to identify predictors of the clinical response at 12 months. RESULTS: A total of 143 patients treated with adalimumab or etanercept were evaluated. Most of the clinical measures were significantly improved at 12 months. However, 31%–51% of the patients did not achieve good clinical control. No differences were observed between adalimumab and etanercept, except for poor functionality at 12 months among patients treated with etanercept. The main predictors of a worse clinical response were female sex, etanercept use, poor functionality, or lower quality of life at baseline. The main adverse reactions were alopecia, headache, injection site reaction, sinusitis, flu, dyslipidemia, and infections. CONCLUSION: TNF inhibitor therapy was effective and safe. However, despite improvements in clinical measures, most patients did not achieve satisfactory control of the disease.

Resumo Os objetivos do estudo foram desenvolver a versão em português da Attention to Body Shape Scale (ABS); estimar as propriedades psicométricas da ABS para dados brasileiros; comparar os escores da ABS entre os sexos e diferentes características amostrais. A versão em português foi desenvolvida seguindo protocolo padronizado. As validades fatorial e convergente foram avaliadas por índices de ajustamento e variância extraída média. A confiabilidade composta e o coeficiente alfa ordinal foram calculados. A invariância do modelo ajustado foi investigada em subamostras independentes por análise multigrupos. Os escores médios da ABS foram comparados entre as variáveis usando ANOVA two-way. Participaram 1.056 indivíduos (71% mulheres) com média de idade de 26,1 (DP=6,4) anos. O item 3 foi excluído da escala devido ao baixo peso fatorial. O modelo refinado apresentou boas propriedades psicométricas aos dados. Diferentes características contribuíram para a maior atenção com a forma corporal. A versão em português da ABS será útil para investigar a atenção com a forma corporal no Brasil. A validade e a confiabilidade dos dados sustentaram a adequação do modelo refinado. Características específicas foram relevantes para investigar a atenção com a forma corporal, portanto, serão úteis para futuros protocolos.

Abstract The objectives of the study were to develop a Portuguese version of Attention to Body Shape Scale (ABS), estimate the psychometric properties of the ABS for Brazilian data, and compare the ABS scores between the sexes and the different sample characteristics. The Portuguese version was developed following a standardized protocol. The factorial and convergent validity were evaluated using goodness-of-fit parameters and average variance extracted. Composite reliability and ordinal coefficient alpha were calculated. The invariance of the fitted model was investigated across independent subsamples using multigroup analysis. The scores were compared between variables using two-way ANOVA. A total of 1,056 individuals (71% female) with a mean age of 26.1 (SD=6.4) years participated in the study. Item 3 was removed due to low factor loading. The refined model presented good psychometric properties for the data. Different characteristics contributed to greater attention to body shape. The Portuguese version of the ABS will be useful to investigate attention to body shape in Brazil. The validity and reliability of the data supported the adequacy of the refined model. Specific characteristics influenced attention to body shape, and therefore, should be considered in future protocols.

Resumo Os objetivos do estudo foram desenvolver a versão em português da Attention to Body Shape Scale (ABS); estimar as propriedades psicométricas da ABS para dados brasileiros; comparar os escores da ABS entre os sexos e diferentes características amostrais. A versão em português foi desenvolvida seguindo protocolo padronizado. As validades fatorial e convergente foram avaliadas por índices de ajustamento e variância extraída média. A confiabilidade composta e o coeficiente alfa ordinal foram calculados. A invariância do modelo ajustado foi investigada em subamostras independentes por análise multigrupos. Os escores médios da ABS foram comparados entre as variáveis usando ANOVA two-way. Participaram 1.056 indivíduos (71% mulheres) com média de idade de 26,1 (DP=6,4) anos. O item 3 foi excluído da escala devido ao baixo peso fatorial. O modelo refinado apresentou boas propriedades psicométricas aos dados. Diferentes características contribuíram para a maior atenção com a forma corporal. A versão em português da ABS será útil para investigar a atenção com a forma corporal no Brasil. A validade e a confiabilidade dos dados sustentaram a adequação do modelo refinado. Características específicas foram relevantes para investigar a atenção com a forma corporal, portanto, serão úteis para futuros protocolos.

Abstract The objectives of the study were to develop a Portuguese version of Attention to Body Shape Scale (ABS), estimate the psychometric properties of the ABS for Brazilian data, and compare the ABS scores between the sexes and the different sample characteristics. The Portuguese version was developed following a standardized protocol. The factorial and convergent validity were evaluated using goodness-of-fit parameters and average variance extracted. Composite reliability and ordinal coefficient alpha were calculated. The invariance of the fitted model was investigated across independent subsamples using multigroup analysis. The scores were compared between variables using two-way ANOVA. A total of 1,056 individuals (71% female) with a mean age of 26.1 (SD=6.4) years participated in the study. Item 3 was removed due to low factor loading. The refined model presented good psychometric properties for the data. Different characteristics contributed to greater attention to body shape. The Portuguese version of the ABS will be useful to investigate attention to body shape in Brazil. The validity and reliability of the data supported the adequacy of the refined model. Specific characteristics influenced attention to body shape, and therefore, should be considered in future protocols.

ABSTRACT Objective To evaluate the therapeutic response (functionality) and its associated factors in patients on biological drugs on the Public Health System for treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Methods An open prospective cohort was carried out from 2011 to 2019, in Belo Horizonte (MG). Functionality was assessed using the Health Assessment Questionnaire Disability-Index at baseline, and after 6 and 12 months of follow-up. Factors associated with poor functionality were identified through logistic regression. Results The median Health Assessment Questionnaire Disability-Index at baseline was 1.5 (interquartile range of 0.8-1.9), with poor functionality observed in patients with rheumatoid arthritis. Improved functionality was seen at 6 months of treatment for the three diseases. The predictors of poor functionality at 6 months for psoriatic arthritis and ankylosing spondylitis were female sex, low education levels, and high disease activity; and for rheumatoid arthritis and psoriatic arthritis were female sex, advanced age, and high disease activity. In 12 months, the three diseases had predictors of worse functionality: female sex, low education, and high disease activity. Conclusion There was a significant improvement in functionality during the follow-up, with better response at 6 months of treatment. Poor functionality was observed in older, female patients, with low education and high disease activity.

RESUMO Explorou-se a influência de diferentes precursores carbonosos no desenvolvimento de fotocatalisadores g-C3N4/xerogel de carbono/ZnO. O acoplamento entre o óxido de zinco e o nitreto de carbono grafítico é adequado para impulsionar a degradação de poluentes orgânicos. A função do xerogel de carbono é melhorar a transferência de cargas e aumentar a atividade do catalisador sob radiação solar. Foram usados diferentes taninos comerciais (PHENOTAN AP, AG e BS) para avaliar o efeito do precursor carbonoso nas propriedades do compósito. O óxido de zinco possui estrutura cristalina hexagonal. A espectroscopia de reflectância difusa mostrou que os materiais absorvem radiação na região do espectro visível, sendo o material preparado com PHENOTAN AP o que apresentou maior capacidade de absorção. A análise de microscopia eletrônica de varredura mostrou que os materiais são compostos por aglomerados de partículas que tendem a esfericidade. A análise de espectroscopia de energia dispersiva, feita apenas para o material PHENOTAN AP, mostrou que os elementos que compõe o material estão homogeneamente distribuídos na matriz. Por meio da isoterma de nitrogênio, observou-se que os materiais possuem isoterma do tipo IV-H3, sendo que o material PHENOTAN AP apresentou a maior área superficial. A análise de distribuição de poros mostrou que o diâmetro de maior ocorrência se encontra entre 20 e 40 nm. Por meio da termogravimetria, observou-se o material sintetizado com PHENOTAN AP apresenta maior estabilidade térmica. Foi observado que o precursor utilizado na síntese dos compósitos influencia significativamente a atividade fotocatalítica dos materiais. O compósito que apresentou a maior eficiência na fotodegradação do 4-clorofenol sob radiação solar foi o preparado com PHENOTAN AP devido à sua capacidade de absorção de radiação superior, maior área superficial e maior volume de poros. Não houve adsorção significativa do 4-clorefenol nos materiais produzidos, assim como não foi verificada lixiviação dos fotocatalisadores ternários durante o processo.

ABSTRACT The influence of different carbonaceous precursors on the development of g-C3N4/carbon xerogel/ZnO photocatalysts was explored. The coupling between zinc oxide and graphitic carbon nitride is suitable for boosting the degradation of organic pollutants. The function of carbon xerogel is to improve charge transfer and increase catalyst activity under visible radiation. Different commercial tannins (PHENOTAN AP, AG and BS) were used to evaluate the precursor effect on the composite’s properties. X-ray diffractometry showed that the materials have the hexagonal crystal structure of zinc oxide. Diffuse reflectance spectra obtained exhibited the characteristic behavior of zinc oxide (λ<420nm). Furthermore, the material prepared with PHENOTAN AP had a superior visible light absorption capacity. The scanning electron microscopy analysis showed that the materials are composed of clusters of particles similar to spheres and the materials in particle size. The dispersive energy spectroscopy analysis was performed only for the material prepared with PHENOTAN AP and evidenced that all elements are well distributed in g-C3N4/carbon xerogel/ZnO matrix. The nitrogen adsorption isotherms of the materials showed that the isotherms characteristics (type IV-H3), whereas the material synthesized with PHENOTAN AP has the largest specific surface area. The pore distribution of the materials showed that the materials had most developed porous structure, with pores ranging from 20 nm to 40 nm. Through thermogravimetry analysis it is possible to observe that the PHENOTAN AP has superior thermal stability. It was observed that the precursor used in the synthesis of composites significantly influences the photocatalytic activity of the materials. The composite with the highest photodegradation efficiency of 4-Chlorophenol under solar radiation was prepared with PHENOTAN AP, since it has a superior visible radiation absorption, greater amount of carbon, greater surface area and greater volume of pores. It is also worth noting that there was no significant adsorption of 4-chlorophenol in the materials synthesized, as well as no leaching of the photocatalysts during the process.

Resumo Objetivo: estimar as propriedades psicométricas do Authentic Leadership Questionnaire (ALQ) aplicado a enfermeiros brasileiros. Método: estudo observacional transversal com amostragem não probabilística. As propriedades psicométricas das versões RATER e SELF do ALQ foram estimadas utilizando-se análise fatorial confirmatória com método de estimação robusto WLSMV. Como índices de qualidade de ajustamento dos modelos, foram utilizados: razão do qui-quadrado pelos graus de liberdade (χ2/gl), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Aproximation (RMSEA) e Standardized Root Mean Squared Residual (SRMR). A confiabilidade dos dados foi analisada por meio do coeficiente alfa ordinal e da confiabilidade composta. Resultados: participaram 181 enfermeiros (sexo feminino: 80,1%; média de idade de 34,6 anos; tempo de trabalho inferior a cinco anos: 76,3%). Os modelos completos da ALQ RATER e ALQ SELF não apresentaram ajustamento adequado. Porquanto, o modelo refinado apresentou melhor ajustamento para a amostra (ALQ RATER: χ2/gl=2,77; CFI=0,97; TLI=0,97; RMSEA=0,10; SRMR=0,05; ALQ SELF: χ2/gl=2,74; CFI=0,94; TLI=0,92; RMSEA=0,10; SRMR=0,08). No modelo ALQ RATER, foram removidos os itens 1, 7 e 13. Devido à alta correlação entre os fatores Transparência Relacional e Perspectiva Moral, foi proposto um modelo trifatorial com base na junção dos fatores acima citados. No modelo ALQ SELF, foram retirados os itens 2, 5, 9 e 10. Do mesmo modo, foi proposto um modelo trifatorial baseado na junção de dois fatores agora denominado Equilíbrio Autoconsciência. Conclusão: os dados obtidos com Authentic Leadership Questionnaire com enfermeiros brasileiros foram válidos e confiáveis.

Abstract Objective: to establish the psychometric properties of the Authentic Leadership Questionnaire (ALQ) applied to Brazilian nurses. Method: cross-sectional observational study with a non-probabilistic sample. The psychometric properties of the RATER and SELF versions of the ALQ were calculated using confirmatory factor analysis with the WLSMV robust estimation method. The following indices were used to assess the goodness-of-fit of the model: chi-square by degrees of freedom (χ2/df), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Approximation (RMSEA) and Standardized Root Mean Squared Residual (SRMR). Data reliability was analyzed using the ordinal coefficient alpha and composite reliability. Results: 181 nurses participated of the study (female gender: 80.1%; mean age of 34.6 years; working time of less than five years: 76.3%). The complete ALQ RATER and ALQ SELF models did not present an adequate fit. Therefore, the refined models presented a better fit to the sample data (ALQ RATER: χ2/df=2.77; CFI=0.97; TLI=0.97; RMSEA=0.10; SRMR=0.05; ALQ SELF: χ2/df=2.74; CFI=0.94; TLI=0.92; RMSEA=0.10; SRMR=0.08). In the ALQ RATER model, items 1, 7 and 13 were excluded. Due to the high correlation between the factors Relational Transparency and Moral Perspective, a three-factor model based on the combination of the factors mentioned above was proposed. In the ALQ SELF model, items 2, 5, 9 and 10 were excluded. Likewise, a three-factor model based on the combination of two factors, now called Self-Awareness Balance, was proposed. Conclusion: the data obtained with the Authentic Leadership Questionnaire with Brazilian nurses were valid and reliable.

Resumen Objetivo: estimar las propiedades psicométricas del Authentic Leadership Questionnaire (ALQ) aplicado a enfermeros brasileños. Método: estudio observacional transversal con muestreo no probabilístico. Las propiedades psicométricas de las versiones RATER y SELF del ALQ se estimaron mediante análisis factorial confirmatorio con el método de estimación robusta WLSMV. Como índices de calidad de ajuste de los modelos se utilizó: razón de chi-cuadrado por grados de libertad (χ2/gl), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Approximation (RMSEA) y Standardized Root Mean Squared Residual (SRMR). La confiabilidad de los datos se analizó mediante el coeficiente alfa ordinal y la confiabilidad compuesta. Resultados: participaron 181 enfermeros (sexo femenino: 80,1%; edad media de 34,6 años; tiempo de trabajo inferior a cinco años: 76,3%). Los modelos completos ALQ RATER y ALQ SELF no mostraron un ajuste adecuado. Por lo tanto, el modelo refinado presentó un mejor ajuste para la muestra (ALQ RATER: χ2/gl=2,77; CFI=0,97; TLI=0,97; RMSEA=0,10; SRMR=0,05; ALQ SELF: χ2/gl=2,74; CFI=0,94, TLI=0,92, RMSEA=0,10, SRMR=0,08). En el modelo ALQ RATER se eliminaron los ítems 1, 7 y 13. Debido a la alta correlación entre los factores Transparencia Relacional y Perspectiva Moral, se propuso un modelo de tres factores basado en la unión de los factores mencionados anteriormente. En el modelo ALQ SELF se eliminaron los ítems 2, 5, 9 y 10. Asimismo, se propuso un modelo trifactorial basado en la unión de dos factores, ahora denominado Equilibrio de Autoconciencia. Conclusión: los datos obtenidos con el Authentic Leadership Questionnaire con enfermeros brasileños fueron válidos y confiables.

Resumo O objetivo do estudo foi avaliar a prevalência e diversidade da fauna endoparasitária, e os fatores de risco associados às infecções em galinhas de fundo de quintal no Estado da Paraíba, Nordeste do Brasil. Dez municípios foram visitados e, em cada um, dez fazendas, para coletar fezes e aplicar um questionário epidemiológico. Fezes de 417 aves foram utilizadas para a realização de testes de OPG (ovos por grama) e OoPG (oocistos por grama). Prevalências de 40,52% (169/417) e 39,08% (163/417) foram observadas para nematoides e coccídios, respectivamente. Em 17% (71/417), infecções mistas por nematoides e coccídios foram observadas. Nematoides da superfamília Heterakoidea estavam presentes em 100% das amostras positivas (169/169), seguidos por Trichuris spp. (57,3%; 97/169). Todos os oocistos de protozoários observados pertenceram ao gênero Eimeria (100%; 163/163). A variável de presença de asas caídas foi considerada como fator associado à infecção por coccídios (odds ratio= 5,412; interval de confiança: 1,179-24,848; p = 0,030). Concluiu-se que é alta a prevalência de nematoides e coccídios em galinhas de fundo de quintal no Estado da Paraíba. Melhorias nas medidas de manejo sanitário, com maior higiene das instalações, associados a um controle químico de parasitos, podem melhorar a produtividade pela redução das taxas de parasitismo gastrointestinal.

Abstract The aim of this study was to evaluate the prevalence and diversity of endoparasitic fauna and the risk factors associated with parasite infections in free-range chickens in the state of Paraíba, northeastern Brazil. Ten municipalities were visited and, in each of them, ten farms, to collect animal feces and apply epidemiological questionnaires. Feces from 417 poultry were used to perform EPG (eggs per gram) and OoPG (oocysts per gram) tests. Prevalences of 40.52% (169/417) and 39.08% (163/417) were observed for nematodes and coccidia, respectively. In 17% (71/417), mixed infections by nematodes and coccidia were observed. Nematodes of Heterakoidea superfamily were present in 100% of the positive samples (169/169), followed by Trichuris spp. (57.3%; 97/169). All the protozoan oocysts observed belonged to the genus Eimeria (100%; 163/163). The variable of presence of drooping wings was considered to be a factor associated with infection by coccidia (odds ratio = 5.412; confidence interval: 1.179-24.848; p = 0.030). It was concluded that there is high prevalence of nematodes and coccidia in free-range chickens in the state of Paraíba, Brazil. Better sanitary management measures, with greater hygiene of facilities, together with chemical control of parasites, can improve productivity by reducing the rate of gastrointestinal parasites.

Abstract Resynchronization protocols have been proposed as a way of shortening females’ unproductive time in the flock, with good results in cattle and sheep. In goats, initial studies have shown that a second progestogen device inserted before luteolysis and pregnancy diagnosis does not interfere with the corpus luteum lifespan or functionality. This study aimed to evaluate the follicular growth, ovulation pattern and pregnancy rate after insertion of a second and new progestogen device for resynchronizing, with or without equine Chorionic Gonadotrophin (eCG), submitted to natural mating (NM) or artificial insemination (AI) to propose a viable resynchronization protocol for dairy goats. A total of 38 multiparous Saanen goats underwent a short-term progesterone protocol [six days exposed to medroxyprogesterone acetate (MAP) intravaginal sponges + 200 IU eCG and 0.12 mg of cloprostenol sodium on the 5th day + 0.025 mg of lecirelin 34 hours after sponge withdrawal] and, on day 16th after the ovulation, received a new MAP device which was retained until day 21. At this moment females were split into four groups: GeCG+NM – 100 IU eCG with NM; GSal+NM – saline solution with NM; GeCG+AI – 100 IU eCG with AI; and GSal+AI – saline solution with AI. Ultrasound scans were performed every 12 h from sponge withdrawal (day 21) until 108 h after sponge withdrawal (day 25) for follicular dynamics evaluation, at 240 h (day 31) for assessing the presence of active corpus luteum, and on day 60 for pregnancy diagnosis. No differences were found regarding ovulation time, synchronization and follicle size. However, GeCG+NM presented a greater estrus manifestation rate (100%) and pregnancy rate (62.5%) when compared to GSal+AI. In conclusion, resynchronization protocols in dairy goats may present satisfactory results.

RESUMO Objetivos Realizar a adaptação transcultural da Social Appearance Anxiety Scale (SAAS) para a língua portuguesa e estimar sua consistência interna em uma amostra de adultos jovens brasileiros. Métodos O processo de adaptação transcultural seguiu referências internacionais baseando-se em cinco etapas (tradução, síntese, retrotradução, avaliação de especialistas e pré-teste) para avaliar as equivalências idiomática, semântica, conceitual e cultural. A consistência interna foi estimada pelo coeficiente alfa ordinal (α). Resultados A versão em português foi apresentada com pequenas alterações em relação à original, mas isso não comprometeu o significado conceitual dos itens. Essa versão foi pré-testada em 30 adultos [mulheres = 56,7%; M idade = 26,0 (DP = 6,2) anos], que compreenderam bem o conteúdo. O tempo médio de preenchimento da escala foi de 4,6 (DP = 0,6) minutos. A consistência interna da escala foi boa (α = 0,95) quando aplicada em uma amostra de 80 adultos [mulheres = 51,2%; M idade = 28,0 (DP = 5,7) anos]. Conclusões A versão em português da SAAS foi equivalente à original nas áreas idiomática, semântica e conceitual. Além dessas, a equivalência cultural foi atendida, pois a versão em português foi bem compreendida pelo público brasileiro. A consistência interna do instrumento foi adequada para a amostra. Os achados deste estudo podem ajudar pesquisadores e clínicos interessados em usar a SAAS em contexto brasileiro para rastrear sintomas característicos de ansiedade social devido à aparência física. Entretanto, antes de usar a SAAS em qualquer protocolo, é importante avaliar suas propriedades psicométricas, especialmente a validade de construto.

ABSTRACT Objectives To perform the cross-cultural adaptation of the Social Appearance Anxiety Scale (SAAS) to the Portuguese language and estimate its internal consistency in a sample of Brazilian young adults. Methods The cross-cultural adaptation process followed international references based on five stages (translation, synthesis, back-translation, expert assessment, and pretest) to assess idiomatic, semantic, conceptual, and cultural equivalence. The internal consistency was estimated by the ordinal alpha coefficient (α). Results The new Portuguese version is presented in this study with minor changes from the original that did not violate the meaning of the items. This version was tested in 30 adults (women = 56.7%, M age = 26.0 [SD = 6.2] years) who understood the content. The participants completed the scale in an average time of 4.6 (SD = .6) minutes. The internal consistency of the scale was good (α = .95) when applied in a sample of 80 adults (women = 51.2%, M age = 28.0 [SD = 5.7] years). Conclusions The new Portuguese version of the SAAS was equivalent to the original in the idiomatic, semantic, and conceptual area. As the Brazilian participants understood the Portuguese version, cultural equivalence was found. The instrument’s internal consistency was adequate to the sample. The findings of this study may help researchers and clinicians interested in using the SAAS in Brazilian context for tracking characteristic symptoms of social anxiety due to physical appearance. However, before using SAAS in any protocol, it is important to evaluate its psychometric properties, especially the construct validity.

Background: Pharmaceutical services in Brazil provide access, supply, and rational use of drugs for all population and an effort has been made to improve the quality of these services. Biological drugs are high-cost drugs supplied in Brazil that can inhibit disease progression and improve the quality of life of psoriatic arthritis (PsA) patients. However, some patients did not achieve therapeutic goals. Objective: To evaluate the medication adherence and persistence of PsA patients treated with tumor necrosis factor inhibitors (anti-TNF) drugs and their associated factors. Methods: A prospective observational study was performed at a single-specialty pharmacy in Belo Horizonte, Brazil. Medication adherence, persistence, and clinical outcomes were evaluated at 12 months of follow-up. Medication persistence was historically compared to overall PsA patients treated in Brazil. Associated factors were identified through log-binomial regression. Results: One hundred ninety-seven PsA patients were included in the study, of whom 147 (74.6%) and 142 (72.1%) had medication adherence and persistence, respectively. Patients treated with infliximab presented the highest adherence (90.5%) and persistence rate (95.2%) in comparison to patients treated with other drugs, except for adalimumab versus infliximab for adherence outcome. All clinical measures significantly improved in patients with medication adherence and persistence. Medication persistence was higher for patients attended by specialty pharmacy than other PsA patients in Brazil. The associated factors to higher medication adherence were lower disease activity by BASDAI, being non-white race, and intravenous drug use. The associated factors to higher medication persistence were lower disease activity by Bath Ankylosing Spondylitis Activity Index (BASDAI), intravenous drug use, non-use of corticoids and non-steroidal anti-inflammatory drugs, and comorbidity. Conclusions: Patients with medication adherence and persistence had significant improvements in clinical measures, functionality, and quality of life. High medication adherence and persistence to biological therapy were observed and associated with lesser disease activity at baseline. Also, medication persistence to PsA patients attended in specialty pharmacy was higher than the overall PsA population in Brazil, which indicates the importance of pharmaceutical services to provide health care and promote the effectiveness and safety of biological therapies.

Resumo Fundamento: O transplante cardíaco é a principal alternativa terapêutica para pacientes com insuficiência cardíaca avançada. Diversos fatores de risco influenciam a sobrevivência desses pacientes, entretanto, poucos estudos acerca do tema estão disponíveis no Brasil. Objetivos: Analisar a sobrevivência de pacientes transplantados cardíacos pelo Sistema Único de Saúde no Brasil entre 2000-2015. Métodos: Trata-se de uma coorte não concorrente, aberta, de pacientes transplantados cardíacos no Brasil. A probabilidade acumulada de sobrevivência foi estimada por Kaplan-Meier e a comparação entre as curvas realizada pelo Teste de Log-Rank. O modelo de Cox foi utilizado para calcular o Hazard-Ratio (HR). As análises foram realizadas ao nível de 95% de confiança. Resultados: A mediana de sobrevivência do transplante cardíaco no Brasil no período foi 8,3 anos. Cada ano adicional na idade do receptor, a ocorrência de infecções e a realização do procedimento cirúrgico na região Sul relacionaram-se ao maior risco de perda do enxerto. Maior proporção de uso dos imunossupressores micofenolato e azatioprina atuou como fator protetor. Conclusões: As análises realizadas fornecem a primeira informação quanto ao tempo de sobrevivência mediana do transplante cardíaco no Brasil. A diferença observada entre as regiões pode estar relacionada aos diferentes protocolos de tratamento adotados no país, principalmente no início dos anos 2000. A proporção de uso de micofenolato e azatioprina como fator protetor sugere que, apesar de não haver diferença entre as estratégias terapêuticas, o uso desses medicamentos pode favorecer a sobrevida de determinados pacientes. O estudo apresenta dados epidemiológicos robustos e importantes para a saúde pública.

Abstract Background: Heart transplant is the main therapeutic alternative for advanced heart failure patients. Several risk factors affect these patients' survival; however, few studies about the topic are available in Brazil. Objectives: To review the survival rates of heart transplant patients in the Brazilian Public Health System (Sistema Único de Saúde - SUS) between 2000 and 2015. Methods: This is a non-concurrent, open cohort study, involving cardiac transplant patients in Brazil. The cumulative survival probability was estimated by the Kaplan-Meier curve, and the curve comparison was done using the Log-Rank test. The Cox model was used to calculate the Hazard-Ratio (HR). Analyses were conducted at the 95% confidence level. Results: The heart transplant survival rate median in Brazil, during the period, was 8.3 years. Each additional year in the recipient's age, the occurrence of infections, and the performance of the surgical procedure in the South Region were associated with a higher risk of graft loss. A higher use ratio of immunosuppressants mycophenolate and azathioprine acted as a protection factor. Conclusions: The analyses conducted provide the first information about the median survival time in heart transplant patients in Brazil. The difference noticed among the geographical regions may be related to the different treatment protocols adopted in the country, especially in the early 2000s. The rate of mycophenolate and azathioprine use as a protection factor suggests that, despite the absence of differences among therapeutic strategies, use of these drugs may favor survival of certain patients. The study provides robust epidemiological data, which are relevant for public health.

RESUMO Objetivo Estimar as propriedades psicométricas de uma escala desenvolvida para avaliar a satisfação/insatisfação com o corpo quando aplicada em uma amostra de estudantes universitários brasileiros. Métodos A validade de construto da escala foi estimada a partir de análise fatorial confirmatória. Os índices Comparative Fit Index (CFI), Tucker-Lewis Index (TLI) e Root Mean Square Error of Approximation (RMSEA) foram utilizados. A variância extraída média (VEM), a confiabilidade composta (CC) e o coeficiente alfa ordinal também foram calculados. Todas as estimativas foram calculadas para as amostras feminina e masculina. Participaram 1.000 estudantes (mulheres = 64,0%). A média de idade para a amostra total foi de 20,92 [desvio-padrão (DP) = 2,40] anos e o índice de massa corporal (IMC) médio foi de 23,24 (DP = 3,97) kg/m2. Resultados A estrutura unifatorial original da escala composta por 24 itens não apresentou ajustamento adequado. Após modificações, o modelo bifatorial composto por 19 itens apresentou ajustamento adequado às amostras masculina e feminina (CFI = 0,922-0,958; TLI = 0,912-0,952; RMSEA = 0,090-0,096), bem como adequada validade convergente (VEM = 0,536-0,668) e confiabilidade (CC = 0,920-0,952; α = 0,916-0,948). Com a reestruturação do modelo fatorial, a denominação “Escala de (In)satisfação com a Aparência Corporal” foi apresentada e a sigla BAS-R foi adotada. Conclusão A partir desses indicadores, pesquisadores e clínicos poderão utilizar essa escala para levantar informações sobre a satisfação/insatisfação com o corpo em universitários.

ABSTRACT Objective This study aimed to estimate the psychometric properties of the Body Area Scale (BAS) applied to a sample of Brazilian university students to support the validity and reliability of the obtained data. Methods We performed confirmatory factor analysis (CFA) using the Comparative Fit index (CFI), Tucker-Lewis index (TLI), and Root Mean Square Error of Approximation (RMSEA). We calculated the average variance extracted (AVE), composite reliability (CR), and ordinal alpha coefficient (α). All estimates were calculated separately for women and men. A thousand students participated (women = 64.0%, mean [M] age = 20.92, standard deviation [SD] = 2.40 years; body mass index (BMI) M = 23.24, SD = 3.97 kg/m2). Results Considering the CFA results, the original unifactorial model (24 items) did not fit data for women and men. Instead, the two-factorial model with 19 items had adequate fit for male and female samples (CFI = 0.922-0.958; TLI = 0.912-0.952; RMSEA = 0.090-0.096), as well as good convergent validity (AVE = 0.536-0.668) and reliability (CR = 0.920-0.952; α = 0.916-0.948). Once BAS was proposed to evaluate satisfaction/dissatisfaction with one’s own body, and considering the reformulation of the factorial model, we proposed a new name for the instrument: Body Appearance (Dis)Satisfaction Scale (BAS-R). Conclusion Professionals can now include the BAS-R in future protocols to evaluate satisfaction/dissatisfaction with the body in Brazilian students.